Essay about The Effects Of Drug Abuse On Human Behavior

1102 Words Jun 29th, 2016 5 Pages
Introduction Cocaine is said to be an effective drug due to its ability to induce a sense of craving and its effectiveness highly correlates to its potential to lead to drug abuse in humans. Despite devastating consequences from drug abuse and addiction, the goal to attain the drug is often placed above others, which is especially shown in animal model experiments. According to the 2014 National Survey of Drug Use and Health an estimate of 1.5 million people aged 12 and older were current users of cocaine. Conditioned place preference (CPP) paradigm was utilized in this study where the mice’s preference of a compartment paired with cocaine to a compartment not paired with cocaine was measured. Conditioned place preference was produced if the mice spent significantly more time in the compartment paired with cocaine as opposed to the other (Prus, James, Rosecrans, 2009). In a preliminary study results showed that HuD transgenic mice had significantly stronger conditioned place preference compared to the wild type control group. HuD, a RNA-binding protein, has multiple target proteins and has been shown to regulate expression of brain derived neurotrophic factor (BDNF) and Ca2+/calmodulin-dependent protein kinase II (CamKII), both playing important roles in drug addiction. In one study it has been demonstrated that BDNF is increased in the NAc, dorsal striatum, and prefrontal cortex (PFC) after a single dose of cocaine and over expression of BDNF leads to enhanced cocaine CPP…

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